iclarke@faculty.ocadu.ca
OCAD University
Ian Clarke
Associate Dean
Faculty of Liberal Arts and Sciences, Graduate Studies
416-977-6000, Ext. 314
iclarke@faculty.ocadu.ca

Area(s) of Expertise

Science (Biology and Chemistry), Biomimicry Design, Printmaking/Photography, Urban Ecology

Overview

Our society is increasingly influenced by science and technology. We face enormous challenges dealing with issues such as climate change, genetic engineering, cloning and the loss of biodiversity and habitat. How our society reacts to these issues will profoundly alter all our lives and may fundamentally alter the structure of society itself. As artists and designers, it is essential to have basic natural science literacy if we are to understand the world around us, and for us to enter into critical discourse about science and technology. As a research scientist, teacher and practicing artist, I find great parallels between the creative thought processes of art and scientific research. I am inspired by the curiosity of the OCAD students who take my Biology course. Curiosity is the driving force for all science.

Education

AOCAD Ontario College of Art & Design, (Printmaking) B.Sc. (Biochemistry) Ph.D. Queen's University (Biochemistry)

Professional Experience

Ian Clarke started teaching at OCAD in 2003 in the Faculty of Liberal Studies. He has taught biology and biochemistry in various capacities at Queen's University and for the British Columbia Open University. He is a Biomimicry 3.8 Institute Fellow and is active in Biomimicry education and research. Previously to joining OCAD University full time he was researching the role of cancer stem cells in brain tumours at the Arthur and Sonia Labatt Brain Tumour Research Centre at the Hospital for Sick Children.

Selected Exhibitions

Is that a Monkey in Your Genes? (part of Go West) AWOL Gallery, Toronto, April 2004 Printers Devils, Le gallery, Toronto, 2004 Go West, Gallery 61, Toronto, April 25-27 2003 Millennium in a Box, Canadian Bookbinders and Book Artist\'s Guild show, exhibited at numerous venues in Canada, the United States, Europe, Australia and New Zealand, 2000-2001 Art of Darkness, Art Gallery of Ontario, Toronto, Nov. 1996 to Feb. 1997 What is the Difference Between Alienated and Collective Cultures?, Artists\' Political Action Collective (APAC), Mercer Union, Toronto, April - May, 1996

Selected Publications

Phedias Diamandis, Jan Wildenhain, Ian D Clarke, Adrian G Sacher, Jeremy Graham, David S Bellows, Erick K M Ling, Ryan J Ward1, Leanne G Jamieson, Mike Tyers & Peter B Dirks, Nature Chemical Biology, May 2007, ?Chemical genetics reveals a complex functional ground state of neural stem cells? Laurent Balenci, Ian D. Clarke, Peter B. Dirks, Nicole Assard, Fran?ois Ducray, Anne Jouvet, Marie-Fran?oise Belin, Jer?me Honnorat and Jacques Baudier. ?IQGAP1 protein specifies amplifying cancer cells in glioblastoma multiforme.? Cancer Research 15 Sept 2006. Sheila K. Singh, Cynthia Hawkins, Ian D. Clarke, Jeremy Squire, Jane Bayani, Takuichiro Hide, Mark R. Henkelman, Michael D. Cusimano, and Peter B. Dirks. ?Human brain tumor growth is exclusively initiated by cancer stem cells.? Nature 23. 2004, 396-401. Sheila K. Singh, Ian D. Clarke, Takuichiro Hide, and Peter B. Dirks. ?Cancer Stem Cells in Nervous System Tumors.? Oncogene 23. 2004, 7267-7273. Sheila K. Singh, Ian D. Clarke, Mizuhiko Terasaki, Victoria E. Bonn, Cynthia Hawkins, Jeremy Squire and Peter B. Dirks. ?Human Brain Tumours Contain A Cancer Stem Cell that Dictates Tumour Phenotype and Self-Renewal In Vitro.? Cancer Research 63(18). 2003, 5821-5828. Clarke, ID and Dirks PB. ?A human brain tumor-derived PDGFR-a deletion mutant is transforming.? Oncogene 22. 2003, 722-733. Kimmel SG, Ohbatake M, Kushida M, Merguerian P, Clarke ID, Kim PC. "Murine xenogeneic immune responses to the human testis: a presumed immune-privileged tissue". Transplantation. 2000 Mar 27;69(6):1075-84. Obatake M, Kushida M, Kimmel S, Clarke ID, Kim PC. T cells are necessary and critical for xenograft rejection in new concordant cardiac xenotransplant model. Transplantation. 1999 Jun 15;67(11):1480-4. M. Ohabatake, I. Clarke, S. Kimmel, M. Kushida, P. Merguerian, A. Marcuzzi, K. Peterson, C. Honey and P. Kim, Is human Testis an Immune Privileged Tissue?, (1998) The FASEB Journal, 12(5):6353 (abstract). Bielaszewska M, Clarke I, Karmali MA, Petric M, Localization of intravenously administered verocytotoxins (Shiga-like toxins) 1 and 2 in rabbits immunized with homologous and heterologous toxoids and toxin subunits. Infect Immun. 1997 Jul;65(7):2509-16. Reymond D, Karmali MA, Clarke I, Winkler M, Petric M., Comparison of the western blot assay with the neutralizing-antibody and enzyme-linked immunosorbent assays for measuring antibody to verocytotoxin 1. J Clin Microbiol. 1997 Mar;35(3):609-13. A. Caprioli, I. Luzzi, L. Seganti, M. Marchetti, M. Karmali, B. Boyd and I. Clarke, (1994), "Frequency and Nature of Verocytotoxin 2 (VT2) Neutralizing Activity in Human and Animal Sera.", from Recent Advances in Verocytotoxin-Producing Escherichia Coli infections, (M.A. Karmali & A.G. Goglio, ed.; Elsevier Science B.V.; Amsterdam).

Professional Affiliations / Boards / Juries

Past Vice-President and Board member of the Canadian Bookbinders and Book Artists Guild, International Society for Stem Cell Research, Canadian Stem Cell Network, Society of Neuro-oncology, Society of Neuroscience,